Endocrine Abstracts

Introduction: Acromegaly is chronic debilitating disease related with excess GH and insülin-like growth factor 1 (IGF1) secretion. Pegvisomant is a GH receptor antagonist that competes with endogenous GH for its receptor and is often used as a medical therapy in patients with inadequate response to somatostatin analogs.Methods: Forty-six patients are followed with the diagnosis of acromegaly in our clinic. We present the results of six acromegalic p...

Sheehan's syndrome occurs as a result of ischemic pituitary necrosis due to severe postpartum haemorrhage. It is characterized by varying degrees of anterior pituitary dysfunction and GH is one of the earliest hormones lost. We have compared patients with Sheehan's syndrome (n=189) and with non-functioning pituitary adenoma (NFPA; n=117) to determine whether adult GH deficient patients with Sheehan's syndrome have different baseline characteristics and whether they respond in ...

The most common cause of a mass lesion in the sella is pituitary adenoma. Some parasellar lesions may be cystic and sometimes may mimic the clinical and radiological features of pituitary adenoma. A 36 year-old woman was admitted to the hospital because of headache for five years and amenorrhoea for five months. Magnetic resonance (MR) imaging of the pituitary gland showed sellar mass lesion characterized by high signal intensity on T1 and T2-weighted images. Endocrinological ...